Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites
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چکیده
منابع مشابه
Rabbit Liver Guanine Deaminase
Homogeneous guanine deaminase (guanine aminohydrolase, EC 3.5.4.3) is a single polypeptide chain of mean molecular weight of 55,000, as determined by Sephadex gel filtration and sodium dodecyl sulfate polyacrylamide disc gel electrophoresis. Irreversible inactivation was observed upon incubation with P-chloromercuribenzoate, at a concentration of 1.0 x lop4 M. Iodoacetic acid and iodoacetamide ...
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Seborrhoeic keratosis (SK) is the most common benign tumor of middle and older ages (1), and can appear in any part of the body except mucous membranes. Its clinical diagnosis is almost always easy and usually offers no problems. Unlike common SK, the inflammatory variety of the disease is often difficult to diagnose and may be clinically confused with basal cell carcinoma, squamous cell carcin...
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1. Guanine deaminase in rat brain and liver was distributed among all the subcellular fractions: nuclei, ;heavy' mitochondria, ;light' mitochondria, microsomes and the supernatant fluid. The greater part of the activity passed into the soluble fraction. Among the particulate components, the ;light' mitochondria constituted the richest fraction. 2. The sum of the enzymic activities of the compon...
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Using the human cDNA sequence corresponding to guanine deaminase, the Escherichia coli genome was scanned using the Basic Local Alignment Search Tool (BLAST), and a corresponding 439-residue open reading frame of unknown function was identified as having 36% identity to the human protein. The putative gene was amplified, subcloned into the pMAL-c2 vector, expressed, purified, and characterized ...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2020
ISSN: 1651-2057
DOI: 10.2340/00015555-3473